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To Schmorl's and Lubarsch's eases of emboli of liver-cells in the cerebral and the renal veins may be added two observations from my laboratory, of which one has been reported by Flexner, of clumps of liver-cells in branches of the renal vein in cases with extensive hepatic necroses (counter).

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Sometimes they are associated with perceptible cost changes; thus the fingers and toes may be white and cold, hot, red and dry, or warm, livid and moist.

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The intensity of the attack may last only a few minutes and rapidly subside; but it sometimes returns in a series of wave-like recurrences through a period of an hour or more (vs). Eecent lymph over the surface of tations on the tricuspid is a severe rheumatic process; not invariably shown by acute joint troubles, but practically without exception by evidences of either acute or old mischief, involving the mitral, and very frequently the aortic valves; by inflammation of the pericardium in more than half the cases, and methemoglobinemia by acute pleurisy in nearly half the cases. Exceptions will be made only undermost unusual circumstances: in.

The valves in their dead state may effectually close the vessels, but in their living state their muscular fibres may, by the pressure of preternatural fluids and preternatural stimulants, be excited into contractions, which may at least partially open the vessels, so as to admit the retrograde motion of the fluids This is highly probable in itself, and it is confirmed by many facts, which can be explained in no 100 other way than by admitting a reversed action of the lymphatics But whatever may be the fate of the doctrine of reversed motion in the fluids of the lymphatic system, it cannot effect my theory. Fibrous tissue is uses very resistant, and is employed where strength is required.

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